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Diabetes is associated with an increased risk of developing dementia and neurodegenerative diseases, which is inversely related to the degree of glucose tolerance and directly to the disease duration [16]
Comparative effectiveness of GLP-1 receptor agonists on glycemic control and weight outcomes: a systematic review

The key finding: tirzepatide, which produces the most weight loss (up to 22.5% body weight), was most frequently linked to telogen effluvium
However, the 503A pathway has its own legal requirements, and the overall regulatory direction for compounded GLP-1s is narrowing

In spite of these limitations, the available data provide a strong rationale for further investigation of GLP-1RAs in psoriatic disease
