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The dosing is completely different between the two medications and it does not translate between them

By inhibiting the naturally occurring enzyme PDE4, which degrades cAMP, with the drug roflumilast they showed that they could skew neurons toward a sustained response

Cell Host Microbe 17 , 260273

So is the risk real

Tuttle KR, Bosch-Traberg H, Cherney DZI, Hadjadj S, Lawson J, Mosenzon O, et al
