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Early Adaptive Thermogenesis Is a Determinant of Weight Loss after Six Weeks of Caloric Restriction in Overweight Subjects. Metabolism , vol

A follow-up extension study found that participants regained approximately two-thirds of lost weight within one year of stopping treatment, highlighting the importance of sustained therapy (Wilding et al., 2022, PMID: 35441470)
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It means the specific formulation, including the B12 additive and the particular compounding process, has not been independently evaluated by the FDA