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Vitamin B6, or pyridoxine, has a lot of important jobs in the human body

While Semaglutide targets the GLP-1 receptor, Tirzepatide is a dual-agonist that targets both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors

As mentioned earlier, a key limitation of incretin therapy in diabetes is the short half-life of native GLP-1, which necessitates frequent administration

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While the profile of exendin-4-mediated signalling is more similar to that of GLP-1, there are differences in receptor engagement by the two peptides that can be rationalised by the structural and dynamic data