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Clinical trials show that diarrhea occurs in approximately 19-30% of patients using these medications for weight management

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Similarly, chronic intermittent administration of GLP-1R agonists to diabetic rodents is associated with inhibition of food intake, improvement of glycemia, and reduction in hemoglobin A1c (HbA1c), demonstrating that repeated administration of GLP-1 is not associated with a diminished therapeutic response in vivo (Szayna et al., 2000

& Ambachew, S