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UCP2 mRNA expression increased after 24 hours of GLP-1 incubation [181]

Key results (Phase 3): In a 68-week Phase 3a trial published in The New England Journal of Medicine , cagrilintidesemaglutide (CagriSema) produced large mean weight loss (reported as ~22.7% at 68 weeks in the main efficacy analysis)

A 2025 Stanford University interview with psychiatrist Anna Lembke touches on positive connections between the dopamine-stabilizing effects of GLP-1 medications on food addictions and the similar needs of patients with other drug addiction issues

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"In my practice, we go down in dose gradually, the same as we go up, in order to monitor changes and maintain control," she says