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Among these, the relevant weight loss often experienced by people with obesity may promote biliary lithogenicity, such as after bariatric surgery

In healthy individuals, the heart derives approximately 60-90% of its energy from fatty acid oxidation 2

The aim of the trial is to investigate the safety, tolerability, pharmacokinetics (the exposure of the trial drug in the body) and pharmacodynamics (the effect of the investigated drug on the body) of insulin 287 in subjects with type 2 diabetes

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The fat content delays emptying, and the refined-carbohydrate component spikes glucose and insulin in a way that, on top of GLP-1 activity, produces symptoms some patients describe as feeling shaky and unwell rather than nauseous