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Large-scale randomized trials specifically designed to measure anxiety outcomes are needed before drawing firm conclusions

Obesity and Weight Studies: Published Phase 2 data (NEJM, 2023) showed up to 24.2% mean body weight reduction at 48 weeks

Glucose-dependent insulinotropic polypeptide promotes lipid deposition in subcutaneous adipocytes in obese type 2 diabetes patients: a maladaptive response

Concerns about thyroid cancer risk and the potential for sarcopenia or bone fragility in older patients further underscore the need for long-term surveillance (Nunn et al., 2024)

Both drug classes demonstrate cardiovascular benefits, with SGLT2 inhibitors particularly effective for heart failure and GLP-1 receptor agonists reducing major adverse cardiovascular events