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10.1073/pnas.84.20.7005

In the 2023 study, 80 percent of participants who took oral semaglutide for weight loss experienced gastrointestinal problems compared with 46 percent of those who took a placebo

Sharma MK, Jalewa J, Holscher C
Current evidence suggests a risk-stratified approach, with most patients able to continue therapy with appropriate precautions, while some higher-risk individuals may benefit from temporary medication adjustments

2015;15:e4
