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Pregnancy, breastfeeding, and recent acute illness require provider discussion

In the long term, while the immediate costs of providing access to GLP-1s may be high, the potential savings from preventing obesity-related diseases could offset these costs

In addition to a number of circumventricular organs [CVOs, e.g., median eminence (ME), area postrema (AP), subfornical organ, organum vasculosum of lamina terminalis], liraglutide was also observed in the hypothalamus [arcuate nucleus (ARC), paraventricular nucleus (PVN), supraoptic NTS, supraoptic decussation], which would have necessitated its uptake across the bloodbrain barrier

Inclusion of GLP-1s for selected high-risk patients could:[6] Prevent costly complications like heart attacks, strokes, and kidney failure

These combinations are not necessarily off-limits, but they require close monitoring and likely dose reductions in the existing diabetes medication