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Because muscle absorbs medications faster than fat, peak drug levels in your blood may spike higher than intended, triggering nausea, vomiting, or dizziness shortly after injection

That said, these numbers come from different studies with different populations and durations

This may be more likely to occur in patients who have a family history of heart disease

However, some people wonder if semaglutide can affect the liver or lead to liver problems like jaundice

Practice Points Type I (sliding) hiatus hernia results from laxity and loss of elasticity of the phrenoesophageal ligament Endoscopy and radiography are relatively insensitive in the detection of small type I hiatus hernias because the exams trigger esophageal shortening and physiological herniation High resolution manometry with pressure topography plotting allows for precise localization and quantification of the individual physiological elements of the esophagogastric junction with minimal perturbation Research Agenda The relationship between reflux disease and the detailed pressure morphology of the esophagogastric junction needs to be re-examined in light of the enhanced capabilities of high resolution manometry Acknowledgments This work was supported by R01 DC00646 (PJK) from the Public Health Service Abbreviations HRM High-resolution manometry LES lower esophageal sphincter EGJ esophagogastric junction Footnotes Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication