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[8,16] Once activated, Akt regulates several crucial downstream mechanisms, including glucose uptake through GLUT3/GLUT4 transporters, stabilization of neuronal membrane potential through Na + /K + -ATPase activity, modulation of GABAergic neurotransmission, and regulation of mitochondrial function through mammalian target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK) pathways

J Pain Symptom Manage 2005

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Since CPP is a behavioral marker of a substances hedonic value, these results indicate that GLP-1RAs may attenuate the affective component of reinforcement, i.e., liking

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