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The Link Between Semaglutide and Gallstones While effective for weight management and diabetes control, semaglutide can increase the risk of gallstonessmall, hard deposits in the gallbladder that can cause pain and serious health issues

Excess weight can alter hormones, increase inflammation and raise cholesterol

If your primary issue is a plateau on semaglutide, a permanent switch to tirzepatide is supported by stronger evidence than alternating

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