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However, as with any medication, potential side effects are an important consideration

Do not use ibuprofen chronically or repeatedly while on semaglutide without explicit approval from your healthcare team

A small meal or snack containing both carbohydrate and protein 60 to 90 minutes before the ride gives your muscles enough available glycogen to sustain moderate effort throughout without borrowing from muscle protein stores

Once you submitted the form, a licensed physician reviews your information to decide if treatment is right for you

Emerging clinical reports suggest that GLP-1 agonists may induce reductions in lean mass, including skeletal muscle, potentially compromising exercise capacity independently of central effects (Karakasis et al., 2025