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The third study added immobilization, a well-established stimulus for muscle wasting, to see if not exercising the muscle would reveal any hidden harmful effects of GLP-1-based drugs on muscle mass

Acknowledgements The authors thank the FILM Facility, Imperial College London for technical support on microscopy experiments and microscopy data analysis, and Prof Mark Sansom and Dr Wanling Song, Dept Biochemistry, University of Oxford, for assistance with the use of PyLipID for the GLP-1R-cholesterol binding site analysis

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Part-2: Studies show that miR-93 is highly expressed in fatty livers, where it suppresses SIRT1, a gene responsible for lipid metabolism