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Keywords: GLP-1 receptor agonist, substance use disorder, craving, reward circuitry, gutbrain axis, mesolimbic pathway, dopamine, synaptic plasticity, vagal signaling, neuroinflammation, semaglutide, addiction 1

By reducing autophagy via the GLP-1R-ERK1/2-histone deacetylase 6 (HDAC6) signaling pathway, GLP-1 treatment enhances diabetic retinopathy (DR)

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Besides inducing considerable weight loss, their impact on the digestive system and metabolism may cause some adverse reactions

Bismuth subsalicylate (Pepto-Bismol) can actually neutralize hydrogen sulfide in the gut, converting it to bismuth sulfide, which is insoluble and odorless