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Unlike Ozempic, Wegovy, Zepbound and Mounjaro, compounded drugs are not FDA-approved, meaning the agency has not reviewed them for safety, effectiveness or quality

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4.5 Pregnancy and maternal-fetal outcomes: limited evidence and risk communication priorities Periconception safety should be framed as an evidence-limited risk-management problem rather than as evidence of safety

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Interestingly, while we do not know the role of GLP-1 in this circuit on food reward several studies have explored the therapeutic potential of nigro-striatal GLP-1 action in animal models of Parkinson's disease (Harkavyi et al., 2008