glp-1 agonist and heart failure receptor agonists (GLP-1RAs): cardiovascular actions therapeutic potential Glucagon-like peptide 1 receptor agonists:

However, it is important to remember that there are no one-size-fits-all weight loss solutions

In this regard, in the pancreatic -cell, elevation of both cAMP and cytosolic Ca 2+ and -arrestin signalling downstream of GLP-1R activation are critical events in promoting glucose-dependent insulin secretion

BDNF, brain-derived neurotrophic factor

doi: 10.1210/clinem/dgab927 24 ZuckerIZloofYBardugoATsurAMLutskiMCohenYet al

Conclusion Emerging evidence underscores the cardioprotective effects of GLP-1RAs, which make them potentially useful for different subpopulations of patients with cardiovascular diseases, including those with HFpEF