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PKA and Epac-2 inhibit the K-channel, altering Kv currents leading to calcium influx as well as calcium release from the endoplasmic reticulum

In a randomized, single-blind, 24-week study, participants assigned to dual therapy of 2 mg weekly of the GLP-1 receptor agonist exenatide (Bydureon, AstraZeneca) and 10 mg daily of the SGLT2 inhibitor dapagliflozin (Farxiga, AstraZeneca) lost more weight than those taking either agent alone or those receiving dapagliflozin and metformin extended-release (Xigduo XL, AstraZeneca) or phentermine/topiramate extended-release (Qsymia, Vivus)

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Currently available GLP-1 receptor agonists include: Exenatide (Byetta, Bydureon BCise) : Available as twice-daily or once-weekly formulations

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