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Description
Plasma levels of OXA are increased during fasting in humans (32) and are lower in obese subjects than normal-weight people (33), suggesting that peripheral OXA modulates food intake as an orexigenic peptide (34)
GLP-1 stands for glucagon-like peptide-1, but dont let the fancy name scare you offits just a helper your body already makes
Furthermore, these augmented non-responders ultimately attained comparable outcomes to patients who initially responded well to behavioral therapy alone
Carlat Verdict: To prevent metabolic side effects when beginning an antipsychotic, start with metformin, but consider a GLP-1 RA for patients who have already been on antipsychotics for a while with a BMI 30 kg/m 2 (or 27 kg/m 2 and obesity-related health problems)
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