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Hypoglycemia : Particularly when used concomitantly with insulin or sulfonylureas, requiring dose adjustment of these agents

The tension is valid and I dont think the people who push on regulatory boundaries are always wrong

In the U.S., pharma manufacturers can set whatever list price (the wholesale acquisition cost) they want because no federal agency imposes a ceiling

This finding adds a layer of complexity to how sex differences are considered and indicates that comparisons should ideally be stratified by pre- vs postmenopausal age, to assess the extent of activational vs organizational contribution to the potentially detected sex difference

GLP-1RAs commonly cause gastrointestinal side effects that are dose-dependent and typically settle once the dose stabilizes