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What this means in plain terms: The broad, shortage-based window that allowed large-scale compounding of these medications has closed

others experience early nausea or low energy that leads to shorter, gentler sessions

However, there is also a possibility that some of the effect may be independent of GLP-1, because DPP-4 inhibition still reduced -cell apoptosis in human islets cultured in the presence of exendin 9-39 (99), suggesting that other mediators might be involved, but it was also suggested that an anti-inflammatory action could have played a role (99)