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Most patients might likely be focused only on weight reduction and stay oblivious to other metabolic and disease protection benefits

doi: 10.7554/eLife.74964 16 BandsmaR.SokollikC.ChamiR.CutzE.BrubakerP
Metformin was first approved in Canada in 1972, and received subsequent FDA approval in the United States in 1995
Everard, A., et al., Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

It has a shorter half-life than semaglutide and tirzepatide, requiring daily injections rather than weekly
