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Key Factors That Can Seriously Influence the Timeline So, why isn't there one single answer to "how long does it take to work?" Because a host of factors can accelerate, decelerate, or otherwise modify the timeline

According to a 2025 systematic review, retatrutide showed the highest weight loss among all medications studied

Injection form release gradually semaglutide and ensures sustainable effect over time

Of note, the dopamine neurons in the ARH also regulate pituitary hormones (71), which could be linked to the GLP-1 stimulatory release of pituitary hormones, such as vasopressin and corticotropin-releasing hormone (72)

Potential Benefits for Treating Substance Use Disorders While their possible use for drug addiction disorders may be relatively new in their overall history, GLP-1s are already on store shelves and ready for prescribing