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doi: 10.1056/NEJMoa2407379 21 AronneLJHornDBle RouxCWHoWFalconBLValderasEGet al

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Overall, these results indicate GLP-1RAs can influence a number of proteinopathies across disease models, although more understanding is required to determine when in the course of disease proteostasis can be modulated to bring about reduced neuronal loss and clinical benefit

GLP-1 restores the intestinal barrier function in DSS-induced colitic mice DSS-induced local and systemic proinflammatory mediators led to the disruption of the intestinal barrier