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Prescribing the drugs to treat substance use, at least for now, isn't possible because they aren't approved by the U.S

Prescribers are advised to: Review eGFR before initiating treatment and consult the relevant SmPC for renal-specific guidance Monitor renal function periodically during therapy, particularly in those with CKD, risk factors, or on nephroactive medicines Counsel patients on adequate hydration, especially during periods of illness or reduced oral intake Patients should always ensure their prescriber is aware of any kidney condition before starting any weight loss medication

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