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Description
The reasons people do not lose weight on semaglutide are usually different from the reasons phentermine fails, which is why cross-class switching can produce different outcomes

Glugacon-like peptide-2: Broad receptor expression, limited therapeutic effect on intestinal inflammation and novel role in liver regeneration
doi: 10.1186/s13054-025-05516-2 58
[DOI] [PubMed] [Google Scholar] Harikumar KG, Ball AM, Sexton PM, Miller LJ
And they can be
