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The semaglutide dose was initiated at 0.25 mg/week for four weeks, followed by 0.5 mg/week for four weeks, and then 1 mg/week for 12 weeks
In trials where semaglutide was added on to basal insulin with or without metformin, severe hypoglycemia (requiring the assistance of another person) was reported in 1.5% of semaglutide-treated patients
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