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Fan C, Zhang J, Qiu D

Significant weight loss typically becomes apparent within the first 2-3 months and continues to accumulate with consistent use

If there are any differences in the PTA calculation, the applicant can contact the patent office within 2 months (extendable to 5 months) following the patent's issue, and if that does not satisfy them, they can launch civil action in the district court within 180 days

Previous medical incidents like blood clots, heart failure, or stroke usually inform how a clinician decides when to stop blood thinners