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some experience no joint symptom change despite weight loss, suggesting metabolic or inflammatory phenotypes that don't respond primarily to weight reduction

doi: 10.1136/bmj.1.5794.199 [DOI] [PMC free article] [PubMed] [Google Scholar] 123

Oral medications may also be used to manage symptoms of rosacea, such as propranolol and clonidine for flushing, doxycycline, and minocycline for inflammatory papules and pustules, and isotretinoin for phyma

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It has demonstrated the ability to reduce body weight by more than 20% in individuals with obesity (118), and to improve glycemic control to a degree that 87-91% of enrolled individuals with type 2 diabetes reach HbA1c levels below the type 2 diabetes diagnostic threshold after 40 weeks of treatment (120)