does semaglutide have to be refrigerated Storage: Refrigeration Rules & Guidelines Do You Have to Refrigerate

Discontinuation rates due to adverse events ranged from 0-6% depending on the dose group, which is comparable to or lower than rates seen with semaglutide (7% in STEP 1) and tirzepatide (4-7% in SURMOUNT-1)

2021;7:e12139 ClinicalTrials.gov

Once activated, active pro-inflammatory cytokines (e.g., IL-18 and IL-1b) are produced, which in turn induce cell death through various mechanisms, thus maintaining intestinal homeostasis

J Am Heart Assoc 13(15):e032228

Key contraindications include pregnancy and breastfeeding, with caution advised in those with thyroid disease, pancreatitis history, or severe gastrointestinal disease