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For example, GLP-1R/GIPR dual agonists seem preferential in treatment of modestly overweight individuals with diabetes, where the emphasis is on metabolic control with lesser requirement for body weight reduction

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Autotaxin promotes the degradation of the mucus layer by inhibiting autophagy in mouse colitis

In a randomized, placebo-controlled Phase 2a trial, PP405 met its primary safety endpoint and secondary pharmacokinetic endpoint, showed no systemic absorption, and was well tolerated across a diverse patient population