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[3] [4] These medications work by mimicking the incretin hormone glucagon-like peptide-1, which enhances insulin secretion, suppresses glucagon release, and significantly reduces appetite primarily through central satiety pathways, with some slowing of gastric emptying (an effect that may attenuate over time)

While effective at achieving and maintaining weight loss, long-term use of incretin mimetics is likely needed to maintain weight since weight regain is common following drug discontinuation, with a return to baseline within a year 12,13

Tirzepatides insulinotropic effects on human islets depend on GIPR activity, according to Ei et al

A retatrutide pen is a pre-loaded auto-injector device containing the peptide retatrutide