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- Used an obesity plus osteoarthritis mouse model and showed semaglutide reduced cartilage degeneration, osteophytes, synovial changes, and pain sensitivity

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Pregnancy, breastfeeding, and certain medications (sulfonylureas, insulin) require dose adjustment or alternative approaches

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Dosing usually starts at 0.25 mg per week for the first four weeks, then increases to 0.5 mg

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