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Molecular communications in the gutbrain axis, between the central nervous system and the gastrointestinal tract, are critical for maintaining healthy brain function, particularly in aging
The success of these agents in preclinical models and clinical trials suggests a promising future for multiagonists in the treatment of metabolic diseases, with the most recent glucose-dependent insulinotropic peptide receptor:glucagon-like peptide 1 receptor:glucagon receptor (GIPR:GLP-1R:GCGR) triagonists rivaling the efficacy of bariatric surgery
