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Figure 2 5 Clinical research progress and safety evaluation 5.1 Clinical efficacy studies Tirzepatide, a novel dual GLP-1 and GIP receptor agonist, has demonstrated remarkable efficacy in the management of type 2 diabetes and obesity, as evidenced by multiple high-quality clinical trials ( Importantly, tirzepatide may influence fat distribution, particularly by reducing visceral and cervical adiposity, which are closely associated with upper airway obstruction in OSAS

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In males with PWS, premature pubarche is associated with early pubic hair growth, elevated levels of serum dehydroepiandrosterone sulfate or serum dehydroepiandrosterone, and advanced bone age

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