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According to Marilyn Tan MD, an associate professor of Medicine at Stanford U

How you manage them depends on the symptoms and severity

Missing doses can disrupt appetite control and lead to rebound hunger, so maintaining consistency is important

In the add-on to basal insulin placebo-controlled study (SURPASS-5), all doses (5, 10 and 15 mg) resulted in significantly greater SBP reductions compared with placebo (ETD [95% CI] 4.4 [ 7.8, 1.0], 6.6 [ 9.9, 3.2] and 10.9 [ 14.3, 7.5] mmHg
