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Furthermore, leptin inhibits insulin secretion by PI3K-dependent activation of phosphodiesterase 3B (PDE3B) and by decreased cAMP levels, thus inhibiting the protein kinase A (PKA) pathway, which is regulates Ca 2+ channels and exocytosis (Marroqui et al., PP-1alpha, the catalytic subunit of protein phosphatase 1 (PP-1), has recently been characterized genetically as a candidate gene for type 2 diabetes

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