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A recent systematic review of GLP-1 agonist exposure found that animal studies showed risks such as fetal growth restriction and skeletal abnormalities, and due to limited human data, experts recommend stopping these medications in both pregnancy and during breastfeeding

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GLP-1 Effects on Kidney Function and Hydration GLP-1 receptor agonists slow stomach emptying and reduce appetite signals, leading many patients to drink less fluid throughout the day simply because thirst signals diminish

5 mg, 4.62 kg

In the pancreas, GLP-1RAs are well known to promote insulin secretion