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Currently, two ongoing clinical trials are investigating the role of GLP-1 RAs in IBD management, that would lead to further knowledge: a French study (ID NCT05196958) evaluating the safety and efficacy of GLP-1 RAs in treatment of DM2 in overweight IBD patients (115), and an American study (ID NCT06774079) comparing the efficacy of GLP-1 RAs tirzepatide versus diet in CD patients (116)

ensuring a stable effect over 24 hours without causing any discomfort

Hong Y, et al

"GLP-1 receptor agonists work to decrease your appetite and help you feel fuller sooner

Heres a typical weekly retatrutide titration schedule: Weeks 1 to 2: 1 mg once a week Weeks 3 to 4: 2 mg once a week Weeks 5 to 8: 4 mg once a week Weeks 9 to 12: 8 mg once a week Week 13 and beyond: 12 mg once a week Not everyone follows the exact same schedule