who qualifies for glp 1 drugs What to Make of the GLP-1 Coverage and Cost Landscape Costly GLP-1 Drugs are Rarely

It fundamentally changes what this class of drugs can achieve

GLP-1 plays a crucial role in glucose homeostasis by stimulating insulin secretion from pancreatic beta cells in a glucose-dependent manner, suppressing glucagon release, and slowing gastric emptying

Our observations about the efficacy of GLP-1 RAs in enhancing survival and reducing cardiovascular events are concordance with evidence from several cardiovascular outcome trials (CVOTs) conducted in general population with T2DM, as well as a recent cohort study focused on solid organ transplant recipients [16,17,18,19, 23]

2023;381:e074068

For example, participants in the trials reported side effects that were generally consistent with previous studies, such as gastrointestinal symptoms, which are one of the main reasons that can lead to discontinuation of the drugs