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Clinicians should exercise caution in individuals with predisposing ocular risk factors, such as small Bruchs membrane opening (BMO), optic disc drusen (ODD), or otherwise crowded optic nerve heads
monotherapy when metformin is considered inappropriate due to intolerance or contraindications, in combination with other medicinal products for the treatment of diabetes.

As with many innovative pharmaceuticals, its benefits come with certain controversies that have sparked debates and discussions in recent times.

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Gynecomastia recurrence rates range from 2-35% depending on technique
