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GLP-1 receptor agonists work by mimicking the incretin hormone GLP-1, which enhances glucose-dependent insulin secretion, suppresses glucagon release, and slows gastric emptying

The purpose of this review is to compare the clinical trial and real-world effectiveness data of second-line therapy with SGLT2-I and GLP-1RA related to A1c reduction, weight loss, cost-effectiveness, and safety in patients with T2DM

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