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Color changes: Persistent redness or darkening of the skin at injection sites suggests chronic irritation

When you start Zepbound, your healthcare provider will initially prescribe a low starting dose, gradually increasing your dose over the next few weeks and months to minimize side effects while maximizing your weight loss on the medication

However, availability and insurance coverage often change as medications become more widely used

Also, glucagon promotes lipolysis in adipose tissue, providing free fatty acids as an alternative energy source during periods of low glucose availability

Your body is still building up to consistent drug levels, and in the meantime, you experience a predictable weekly pattern that many people find discouraging