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One study showed that the introduction of liraglutide increased AMPK phosphorylation and reduced phospho-IKK/ S176/S180, phospho-NF-B p65, phospho-JAK2, phospho-STAT3, SOCS3, TNF-, and IL-6 levels

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes

[DOI] [PubMed] [Google Scholar] 1026.Ahren B., Yamada Y., Seino Y

Careful consideration of patient selection criteria and possible side effects, such as gastrointestinal discomfort and hypoglycemia, will be important when using GLP-1RAs for the treatment of IIH

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