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The combination of excellent glucose control, substantial weight loss, cardiovascular protection, and kidney benefits makes these medications the clear first choice for many patients

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Clinical trials supporting semaglutide approvals tested the drug in patients across varying meal states

16 Severe weight cycling is associated with an increased risk of muscle loss and sarcopenic obesity, 15 , 17 which has been reported in as many as 20% of young women (18 years of age) seeking obesity treatment

Animal studies have raised concerns including smaller fetuses, delayed bone development, skeletal changes and pregnancy loss, especially when mothers lose a significant amount of weight during early fetal development