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Other studies showed no effect of exenatide for 13 weeks (108, 109) or liraglutide for 13 weeks (121)

Fatigue and weakness may occur, particularly during the initial treatment period as the body adjusts to the metabolic effects of the medication

But GLP-1s also come with some tricky-to-manage side effects

LMICs Low- and middle-income countries HICs High-income countries NK cells Natural killer cells TNF- Tumor necrosis factor- IL-1 Interleukin-1 IL-6 Interleukin-6 TLR-4 Toll-like receptor-4 LPS Lipopolysaccharide NLRP3 NOD-like receptor protein 3 ROS Reactive Oxygen Species NO Nitric oxide SIM Sepsis-induced Myopathy GLP-1R Glucagon-like peptide-1 receptor GLP-1 Glucagon-like peptide-1 GLP-1RA Glucagon-like peptide-1 receptor agonist PKA Protein kinase A PLC Phospholipase C ERK1/2 Extracellular signal-regulated kinase 1 and 2 DPP-4 Dipeptidyl peptidase-4 IL-1 Interleukin-1 MCP-1 Monocyte Chemoattractant Protein-1 IL-10 Interleukin-10 iNOS Inducible nitric oxide synthase eNOS Endothelial nitric oxide synthase CRP C-reactive protein MDA Malondialdehyde 8-OHdG 8-hydroxy-2deoxyguanosine ICU Intensive Care Unit SOD Superoxide dismutase GPx Glutathione peroxidase Nrf2 Nuclear factor erythroid 1-related factor 2 SAE Sepsis-associated encephalopathy mTOR Mammalian target of rapamycin DPP-4is Dipeptidyl peptidase-4 inhibitors Glossary References 1

LFC, liver fat content