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Food and Drug Administration (FDA) announced that theyve cleared the first generic GLP-1 injectable to improve glycemic control in adults and pediatric patients aged 10 years and older with type 2 diabetes as an adjunct to diet and exercise. This language likely means that the drug will be available only to diabetics, in contrast to some of the name-brand medications in this class which have been approved for some weight loss cases

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Semaglutide and tirzepatide slow digestion, increasing the risk of aspiration during sedation

Although GLP-1RAs can reduce inflammatory signaling, this effect does not necessarily ensure that precursor inflow remains proportionate to ongoing NAD turnover [75, 105]