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The concern would be, the genetic change would be permanent so if there is over-expression which may change with various states weight loss, illness, aging, hormonal changes it could cause problems from over-expression with no way to reverse, except remove the pancreas or treated muscle, Kohn said in an email
this may be explained by a difference in baseline characteristics
It may be combined with energy-based devices or metabolic programmes under close supervision, depending on medical suitability.
Management of comorbidities is essential
Circulation 109:962965
