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Calls to poison control centers about semaglutide, the active ingredient in Ozempic and Wegovy, are on track to roughly double for the second year in a row.

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Future research should prioritize mechanistic studies and randomized controlled trials designed to clarify optimal dosing, treatment duration, and patient selection, as bridging psychiatry and endocrinology through metabolic interventions could redefine treatment paradigms for bipolar disorder.

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